Soluble alpha klotho and its relation to kidney function and fibroblast growth factor-23
نویسندگان
چکیده
Alexandra Scholze, Ying Liu, Lise Pedersen, Shengqiang Xia, Heinz J. Roth, Berthold Hocher, Lars Melholt Rasmussen, and Martin Tepel Clinical Research Unit, Department of Nephrology, Odense University Hospital, Odense, Denmark; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark; Centre for Individualized Medicine in Arterial Diseases (CIMA), Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark; Labor Dr Limbach und Kollegen, Medizinisches Versorgungszentrum, Heidelberg, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany ClinicalTrials.gov: Identifier NCT00968877.
منابع مشابه
Klotho Protein,A Biomarker for AKI
Klotho is an anti-aging single-pass membrane protein that is mainly produced in the kidney. The level of soluble klotho decreases with age and the klotho gene is associated with an increased risk of age-related diseases, such as diabetes, skin atrophy, chronic kidney disease, ataxia and cancer. The klotho gene is composed of five exons and encodes a membrane glycoprotein located in the plasma ...
متن کاملSerum soluble Klotho protein level is associated with residual diuresis in incident peritoneal dialysis patients.
AIM Active vitamin D (1,25-dihydroxyvitamin D₃), PTH, fibroblast growth factor-23 (FGF-23) and Klotho protein are key regulators of phosphate metabolism. Hyperphosphatemia and increased FGF-23 level in patients with end-stage renal disease are associated with increased morbidity and mortality. The relationships among key regulators of phosphate metabolism are still being investigated. FGF-23, t...
متن کاملIn search of the fountain of youth.
In Greek mythology, Klotho spins the thread of life. In human biology, Klotho protein was so named when researchers discovered that mutations that interrupt its normal function result in a shorter thread of life that is attributable to accelerated aging.1 From its initial discovery, the kidney and its role in phosphate and calcium handling have been at the epicenter of the Klotho story. a, b, a...
متن کاملEffect of High Intensity Interval Training on the Level of Atrial Fibrillation, Fibroblast Growth Factor 23 and Klotho Protein in Male Rats with Renal Failure
Introduction: Cardiovascular problems and atrial fibrillation is one of the most prevalent secondary consequences in hemodialysis patients. This study aimed to examine the effect of high intensity interval training on the level of atrial fibrillation, fibroblast growth factor 23 and Klotho in male rats with chronic kidney disease. Methods: In this study, 30 male rats Wistar (7-8 weeks) were ra...
متن کاملSoluble klotho may be a marker of phosphate reabsorption
Background: Membrane-bound α-klotho functions as a co-receptor with fibroblast growth factor receptor at the renal tubule conferring specificity to fibroblast growth factor-23 (FGF-23), allowing it to inhibit tubular phosphate reabsorption at physiological concentrations. α-klotho also exists as a soluble protein. However, the complex interrelationships between soluble α-klotho (sKl), FGF-23 an...
متن کامل